Chimeras of human lysozyme and α-lactalbumin: an interesting tool for studying partially folded states during protein folding

Protein folding is an extremely active field of research where biology, chemistry, computer science and physics meet. Although the study of protein-folding intermediates in general and equilibrium intermediates in particular has grown considerably in recent years, many questions regarding the conformational state and the structural features of the various partially folded intermediate states remain unanswered. Performing kinetic measurements on proteins that have had their structures modified by site-directed mutagenesis, the so-called protein-engineering method, is an obvious way to gain fine structural information. In the present review, this method has been applied to a variety of proteins belonging to the lysozyme/α-lactalbumin family. Besides recombinants obtained by point mutations of individual critical residues, chimeric proteins in which whole structural elements (10 – 25 residues) from α-lactalbumin were inserted into a human lysozyme matrix are examined. The conformational properties of the equilibrium intermediate states are discussed together with the structural characterization of the partially unfolded states encountered in the kinetic folding pathway. Received 28 May 1998; received after revision 6 July 1998; accepted 6 July 1998     

实时控制计算微分代数系统的代数约束算法

本文结合实际的航天工程背景，针对飞行器轨道约束实时控制模型问题进行了算法研究。首先分析了ＢＤＦ方法用于飞行器轨道约束实时控制模型问题时的缺陷，其后针对实际问题的特点构造了具有三阶收敛的代数约束算法，分析了该算法的数值稳定性，并对潜地式弹道约束实时控制问题及指标（ｉｎｄｅｘ）为２的单摆模型问题进行了实际仿真计算，理论分析以及数值结果表明代数约束算法对指标为２的半显式微分代数系统的实时控制计算是非常有效的。     

Introduction: integrins, dynamic cell receptors

Integrins are a family of adhesive receptors consisting of α- and β-subunits which attach cells together via adhesive protein ligands or bind cells to extracellular matrix. They are found on virtually all cell types and link the external ligand to the cytoskeleton of the cell. Integrins also act as signal transducers both from the outside of the cell to the interior and also inside-out. Their main functions are in recognition and in tight but regulated binding. The series of reviews presented here cover both basic aspects of integrin function, including signal transduction, snake disintegrins and structure and function of I-domains in some integrin α-subunits, as well as the role of integrins in diseases, cancer, inflammation and cardiovascular diseases. The search for suitable inhibitors of integrins for treatment of these diseases and future prospects for their use are also discussed.     

老年人电视胸腔镜手术32例

探讨电视胸腔镜手术（ＶＡＴＳ）在老年人胸部疾病治疗中的价值。方法：１９９６年６月至１９９８年２月，对３２例年龄为６０～８２（平均６８３）岁的老年人施行ＶＡＴＳ，其中局限性肺切除１０例，肺叶切除５例，肺大泡切除３例，肺癌分期５例，胸膜活检、切除及固定术６例，血胸清肺修补、纵隔肿瘤切除及食管裂孔疝补术各１例。占同期ＶＡＴＳ手术的３７７％。结果：全组无死亡。术后并发症发生率为２１９％。结论：由训练有素并充分了解老年人临床特点的胸外科医生施行ＶＡＴＳ是安全可行的     

老年人贫血的诊断

老年人贫血的诊断应具有完整的病史、全面的体检、常规的化验及生化、骨髓检查，必要时尚须作特殊检查，方可确定．     

Ni2B分子结构及成键特性的abinitio计算研究

本文用ＤＦＴ方法对Ｎｉ２Ｂ分子双重态和四重态两种多重度进行高水平的ａｂｉｎｉｔｉｏ计算，结果发现Ｂ以ｓｐ，ｓｐ＾２两种杂化方式同Ｎｉ成键，并且Ｂ带有相反的电荷；体系存在多个区域极小点。     

气动自激振动系统数值解及分析

给出了气动自激振动系统的模型和运动方程，通过数值求解方法研究了系统在不同参数下的振动情况，揭示了系统参数对系统振动特性的影响，为气动自激振动机械的参数设计提出了依据。     

马蹄映射Cantor分形图计算机构造及其混沌分维特性

马蹄映射是具有无穷多个周期点的结构稳定的混沌动力学研究中第一个经典型例子。     

论编辑活动的受制性与能动性

编辑活动受到一定社会的生产力、生产关系以及社会文化事业发展水平的制约，但编辑活动又不是消极被动的，它反过来又对一定的经济、政治以深刻的影响，这种主要通过精神产品（出版物）的内容表现出来的影响和作用就是编辑活动本身所具有的能动性．     

仙人洞维管植物分布区类型

报道仙人洞维管植物分布区类型．